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Lira (GLP-1R) can reduce the occurrence of hepatic steatosis in vivo and in vitro by enhancing autophagy and lipid degradation through the GLP-1R-transcription factor EB (TFEB)-mediated autophagy lysosomal pathway [37]

Senescent cells promote tissue NAD + decline during ageing via the activation of CD38 + macrophages

doi: 10.1038/s41467-020-19638-4

(2) GH replacement therapy can literally subtract years from ones apparent age and is among the most powerful anti-aging strategies available today but at a cost: injections of recombinant human growth hormone (rhGH) are prohibitively expensive, not readily available, and not without side effects and negative consequences, as well see below